No role of matrixmetalloproteinase-3 genetic promoter polymorphism 1171 as a risk factor for cirrhosis in alcoholic liver disease.

@article{Stickel2008NoRO,
  title={No role of matrixmetalloproteinase-3 genetic promoter polymorphism 1171 as a risk factor for cirrhosis in alcoholic liver disease.},
  author={Felix Stickel and Christoph H Osterreicher and Juliane Halangk and Thomas Berg and N. P. Homann and Claus Hellerbrand and Eleonora Patsenker and Vreni Schneider and Armin Kolb and Helmut Friess and Detlef B Schuppan and Gero Puhl and Helmut Karl Seitz and Julian L B Leathart and Christopher Paul Day},
  journal={Alcoholism, clinical and experimental research},
  year={2008},
  volume={32 6},
  pages={959-65}
}
BACKGROUND As only a minority of alcoholics develop cirrhosis, polymorphic genes, whose products are involved in fibrosis development were suggested to confer individual susceptibility. We tested whether a functional promoter polymorphism in the gene encoding matrix metalloproteinase-3 (MMP-3; 1171 5A/6A) was associated liver cirrhosis in alcoholics. METHODS Independent cohorts from the UK and Germany were studied. (i) UK cohort: 320 alcoholic cirrhotics and 183 heavy drinkers without liver… CONTINUE READING

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Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva • 2008
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