No role of interleukin-4 in CD23/IgE-mediated enhancement of the murine antibody response in vivo.

@article{Hjulstrm1995NoRO,
  title={No role of interleukin-4 in CD23/IgE-mediated enhancement of the murine antibody response in vivo.},
  author={S Hjulstr{\"o}m and Anders Landin and Liselotte Jansson and Rikard Holmdahl and B Heyman},
  journal={European journal of immunology},
  year={1995},
  volume={25 5},
  pages={1469-72}
}
Antigen-specific IgE up-regulates the specific IgM, IgG1, IgG2a and IgE response in vivo when given to mice together with antigen. The enhancement is mediated by the low-affinity receptor for IgE, Fc epsilon RII or CD23, as demonstrated both in CD23-deficient mice and by blocking CD23 with anti-CD23 monoclonal antibodies. A possible mechanism behind the regulatory effects of CD23 is that the IgE/CD23/antigen complex is endocytosed by B cells, leading to increased antigen processing and… CONTINUE READING
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