No-reflow phenomenon persists long-term after ischemia/reperfusion in the rat and predicts infarct expansion.

@article{Reffelmann2003NoreflowPP,
  title={No-reflow phenomenon persists long-term after ischemia/reperfusion in the rat and predicts infarct expansion.},
  author={Thorsten Reffelmann and Sharon L. Hale and Joan S. Dow and Robert A. Kloner},
  journal={Circulation},
  year={2003},
  volume={108 23},
  pages={2911-7}
}
BACKGROUND No-reflow after reperfusion therapy for myocardial infarction is a strong predictor of clinical outcome. But its fate on a long-term basis and potential significance for infarct healing are not yet known. METHODS AND RESULTS Twenty-nine female Fisher rats were subjected to 60 minutes of coronary occlusion followed by reperfusion. At 4 weeks, 15 survivors were euthanized after measurement of regional myocardial blood flow (radioactive microspheres) and in vivo staining of perfused… CONTINUE READING