No reduction of blood glucose in diabetic rats after oral administration of insulin liposomes prepared under acidic conditions.

Abstract

Insulin liposomes (dipalmitoyl phosphatidylcholine or dimyristoyl phosphatidylcholine/cholesterol = 7/2) were prepared under strongly acidic conditions maintaining the biological activity of insulin. Although these were apparently noncharged liposomes, the association of insulin with membrane of liposomes was unexpectedly very large, and the uptake % of… (More)

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