No reason to reconsider HIF-2 as an oncogene in neuroblastoma and other cancer forms.

Abstract

Westerlund et al. (1) conclude that HIF-2α is linked to neuroblastoma suppression, contradicting several previous observations and current views of the role of HIF-2 in tumorigenesis. We believe that their conclusions are based on flawed cellular models and inappropriate interpretations of their own and public neuroblastoma expression data, as detailed… (More)
DOI: 10.1073/pnas.1716644115

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