No pain, no gain: the useful function of angina.

@article{Bolli2005NoPN,
  title={No pain, no gain: the useful function of angina.},
  author={Roberto Bolli and Ahmed A Abdel-Latif},
  journal={Circulation},
  year={2005},
  volume={112 23},
  pages={3541-3}
}
Myocardial ischemia, the major cause of mortality and morbidity in the United States, accounts for nearly 20% of all deaths.1 The prognosis of patients with acute myocardial infarction is strongly related to the amount of tissue destroyed during ischemia/reperfusion; hence, limiting this injury is of paramount importance for reducing the morbidity and mortality associated with ischemic heart disease.2,3 Over the past 40 years, several hundred pharmacological or nonpharmacological therapies have… CONTINUE READING