No mutations of SAP/SH2D1A/DSHP and perforin genes in patients with Epstein-Barr virus-associated hemophagocytic syndrome in Japan.

@article{Ma2001NoMO,
  title={No mutations of SAP/SH2D1A/DSHP and perforin genes in patients with Epstein-Barr virus-associated hemophagocytic syndrome in Japan.},
  author={Xiaoming Ma and Atsushi Okamura and M Yosioka and Nobuhisa Ishiguro and Hideaki Kikuta and Koju Kobayashi},
  journal={Journal of medical virology},
  year={2001},
  volume={65 2},
  pages={358-61}
}
Recently, mutations of two genes, SAP/SH2D1A/DSHP and perforin genes, have been identified in two fatal inherited lymphoproliferative diseases, X-linked lymphoproliferative disease and familial hemophagocytic lymphohistiocytosis, respectively. Epstein-Barr virus (EBV)-associated hemophagocytic syndrome, a fulminant non-inherited T-cell lymphoproliferative disease, is relatively common in Japan and is extremely difficult to distinguish from X-linked lymphoproliferative disease and familial… CONTINUE READING
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