No mutation in the entire coding region of the alpha-synuclein gene in pathologically confirmed cases of multiple system atrophy.

@article{Ozawa1999NoMI,
  title={No mutation in the entire coding region of the alpha-synuclein gene in pathologically confirmed cases of multiple system atrophy.},
  author={Tetsutaro Ozawa and Hiroki Takano and Osamu Onodera and Hiroko Kobayashi and Takeshi Ikeuchi and Reiji Koide and Kaoru Okuizumi and Takayoshi Shimohata and Kenji Wakabayashi and Hitoshi Takahashi and Shoji Tsuji},
  journal={Neuroscience letters},
  year={1999},
  volume={270 2},
  pages={110-2}
}
To determine whether mutations in the coding region of the alpha-synuclein gene are relevant in cases of multiple system atrophy (MSA), detailed nucleotide sequence analysis of the alpha-synuclein gene was performed using total RNA obtained from autopsied brain specimens of 11 pathologically confirmed cases of MSA. The brain specimens used in this study contained both gray and white matter, which were dissected from the frontal, temporal or occipital lobe. No nucleotide alterations were found… CONTINUE READING

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