No missense mutation of WKL1 in a subgroup of probands with schizophrenia

@article{Devaney2002NoMM,
  title={No missense mutation of WKL1 in a subgroup of probands with schizophrenia},
  author={Joseph M. Devaney and Elizabeth A. Donarum and Kevin M Brown and Jobst Meyer and Gerald Stoeber and K. Peter Lesch and Gerald Nestadt and Dietrich A. Stephan and Ann E Pulver},
  journal={Molecular Psychiatry},
  year={2002},
  volume={7},
  pages={419-423}
}
Recently, a Leu309Met mutation in WKL1 (MLC1, KIAA0027), a gene mapped to chromosome 22q13.33, was reported to co-segregate with periodic catatonia, a clinical sub-type of schizophrenia, in seven members of an extended pedigree.1 WKL1 encodes a putative membrane protein expressed exclusively in the brain, particularly in the amygdala, nucleus caudatus, thalamus, and hippocampus.1 We screened WKL1 for etiologic mutations in 28 probands from the United States who were given a consensus diagnosis… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 19 REFERENCES

Splitting schizophrenia : periodic catatoniasusceptibility locus on chromosome 15 q 15

  • G Stober, K Saar, F Ruschendorf, J Meyer, G Nurnberg, S Jatzke
  • Am J Hum Genet
  • 2000

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