No major schizophrenia locus detected on chromosome 1q in a large multicenter sample.

  title={No major schizophrenia locus detected on chromosome 1q in a large multicenter sample.},
  author={Douglas F. Levinson and Peter Holmans and Claudine Laurent and Brien Riley and Ann E Pulver and Pablo V. Gejman and Sibylle G. Schwab and Nigel W. Williams and Michael J Owen and Dieter D B Wildenauer and Alan R. Sanders and Gerald Nestadt and B. J. Mowry and Brandon K. Wormley and St{\'e}phanie Bauch{\'e} and St{\'e}phane Soubigou and Robert Ribble and Deborah A. Nertney and Kung Yee Liang and Laura Martinolich and Wolfgang Maier and Nadine Norton and Hywel Williams and Margot Albus and Eric B Carpenter and Nicola DeMarchi and Kelly R. Ewen-White and Dermot Walsh and Maurice Jay and Jean-Francois Deleuze and Francis Anthony O'Neill and George Papadimitriou and Ann N Weilbaecher and Bernard Lerer and Michael C. O'Donovan and Dimitris G. Dikeos and Jeremy M. Silverman and Kenneth S. Kendler and Jacques Mallet and Raymond R. Crowe and Marilyn K. Walters},
  volume={296 5568},
Reports of substantial evidence for genetic linkage of schizophrenia to chromosome 1q were evaluated by genotyping 16 DNA markers across 107 centimorgans of this chromosome in a multicenter sample of 779 informative schizophrenia pedigrees. No significant evidence was observed for such linkage, nor for heterogeneity in allele sharing among the eight individual samples. Separate analyses of European-origin families, recessive models of inheritance, and families with larger numbers of affected… CONTINUE READING