No isochores in the human chromosomes 21 and 22?

  title={No isochores in the human chromosomes 21 and 22?},
  author={David H{\"a}ring and J. Kypr},
  journal={Biochemical and biophysical research communications},
  volume={280 2},
The human genome is described in the literature as being composed of the isochores, i.e., long (hundreds of kilobases) segments with a homogeneous (G + C) content. We calculated the (G + C) content variations along the DNA molecules of the human chromosomes 21 and 22 and found the variations to be higher everywhere compared to the randomized sequences. Hence the (G + C) content is certainly not homogeneous on the isochore scale in the two human chromosomes. In addition, we found no significant… CONTINUE READING

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