No independent associations of LMP2 and LMP7 polymorphisms with susceptibility to develop IDDM.

@article{Undlien1997NoIA,
  title={No independent associations of LMP2 and LMP7 polymorphisms with susceptibility to develop IDDM.},
  author={D E Undlien and Hanne E Akselsen and Geir Joner and Knut Dahl-J\orgensen and Oddmund S\ovik and Kjersti S R\onningen and Erik Thorsby},
  journal={Diabetes},
  year={1997},
  volume={46 2},
  pages={307-12}
}
Results from a recent study suggested that polymorphisms within the HLA class II genes LMP2 and LMP7 were associated with the susceptibility for developing IDDM, and that this association could not be explained by linkage disequilibrium to HLA-DR or -DQ genes. We typed 285 IDDM patients and 337 HLA-DRB1-DQA1-DQB1 genotypically matched control subjects from an ethnically homogeneous population for both the G/T polymorphism in intron 6 of the LMP7 gene and the Arg-His polymorphism in the LMP2… CONTINUE READING