No genotoxicity in rat blood cells upon 3- or 6-month inhalation exposure to CeO2 or BaSO4 nanomaterials.

@article{Cordelli2017NoGI,
  title={No genotoxicity in rat blood cells upon 3- or 6-month inhalation exposure to CeO2 or BaSO4 nanomaterials.},
  author={Eugenia Cordelli and Jana Keller and Patrizia Eleuteri and Paola Villani and Lan Ma-Hock and Markus Schulz and Robert Landsiedel and Francesca Pacchierotti},
  journal={Mutagenesis},
  year={2017},
  volume={32 1},
  pages={13-22}
}
In the course of a 2-year combined chronic toxicity-carcinogenicity study performed according to Organisation for Economic Co-operation and Development (OECD) Test Guideline 453, systemic (blood cell) genotoxicity of two OECD representative nanomaterials, CeO2 NM-212 and BaSO4 upon 3- or 6-month inhalation exposure to rats was assessed. DNA effects were analysed in leukocytes using the alkaline Comet assay, gene mutations and chromosome aberrations were measured in erythrocytes using the flow… CONTINUE READING