No genetic association between polymorphisms in the Fyn kinase gene and age of schizophrenic onset.

@article{Ohnuma2003NoGA,
  title={No genetic association between polymorphisms in the Fyn kinase gene and age of schizophrenic onset.},
  author={Tohru Ohnuma and Nobuto Shibata and Yoichiro Matsubara and Satoshi Sato and Mitsuru Yamashina and Heii Arai},
  journal={Neuroscience letters},
  year={2003},
  volume={343 1},
  pages={70-2}
}
Since the mRNA level of Fyn, a neurodevelopmental molecule, expression had been reported to be increased in postmortem schizophrenic prefrontal cortex and showed a strong correlation with age of disease onset, we investigated whether the three polymorphisms of the Fyn gene on genomic DNA (-93A/G, IVS10+37T/C and Ex12+894T/G) also had an effect on clinical onset in 139 unrelated schizophrenics. A comparison of the age of onset among the groups classified by polymorphisms showed no significant… CONTINUE READING