No evidence that mRNAs have lower folding free energies than random sequences with the same dinucleotide distribution.

@article{Workman1999NoET,
  title={No evidence that mRNAs have lower folding free energies than random sequences with the same dinucleotide distribution.},
  author={Christopher T. Workman and Anders Krogh},
  journal={Nucleic acids research},
  year={1999},
  volume={27 24},
  pages={4816-22}
}
This work investigates whether mRNA has a lower estimated folding free energy than random sequences. The free energy estimates are calculated by the mfold program for prediction of RNA secondary structures. For a set of 46 mRNAs it is shown that the predicted free energy is not significantly different from random sequences with the same dinucleotide distribution. For random sequences with the same mononucleotide distribution it has previously been shown that the native mRNA sequences have a… CONTINUE READING
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