No evidence of mutations in the P450 aromatase gene in patients with polycystic ovary syndrome.

@article{Sderlund2005NoEO,
  title={No evidence of mutations in the P450 aromatase gene in patients with polycystic ovary syndrome.},
  author={Daniela S{\"o}derlund and Patricia Canto and Sebasti{\'a}n Carranza-Lira and Juan Pablo M{\'e}ndez},
  journal={Human reproduction},
  year={2005},
  volume={20 4},
  pages={965-9}
}
BACKGROUND Etiology and inheritance pattern in polycystic ovary syndrome (PCOS) remain uncertain. Granulosa cells from follicles of women with PCOS have little, if any, aromatase (encoded by the CYP19 gene) activity; follicles contain low levels of estradiol, P450arom mRNA and aromatase stimulating bioactivity. Mice with targeted disruption of the CYP19 gene present cystic follicles. It has been proposed that chronic exposure to high levels of LH, because of aromatase deficiency, determines the… CONTINUE READING

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