No evidence of correlation between polymorphism at codon 72 of p53 and risk of cervical cancer in Japanese patients with human papillomavirus 16/18 infection.

@article{Minaguchi1998NoEO,
  title={No evidence of correlation between polymorphism at codon 72 of p53 and risk of cervical cancer in Japanese patients with human papillomavirus 16/18 infection.},
  author={T Minaguchi and Y Kanamori and M Matsushima and H Yoshikawa and Y Taketani and Y Nakamura},
  journal={Cancer research},
  year={1998},
  volume={58 20},
  pages={4585-6}
}
  • T Minaguchi, Y Kanamori, +3 authors Y Nakamura
  • Published 1998 in Cancer research
Human papillomavirus (HPV)-16 and -18 encode E6 oncoprotein, which binds to and induces degradation of the tumor suppressor protein p53. A common polymorphism of p53, encoding either proline or arginine at position 72, affects the susceptibility of p53 to E6-mediated degradation in vivo; Caucasian women homozygous for arginine 72 reportedly are about seven times more susceptible to HPV-associated carcinoma of the cervix than heterozygotes. To examine whether arginine 72 could be a risk factor… CONTINUE READING