No evidence of cerebral oedema in severe acute mountain sickness.

  title={No evidence of cerebral oedema in severe acute mountain sickness.},
  author={Rainald Fischer and Christian Vollmar and Matthias Thiere and Christine Born and Michael D. Leitl and Th Pfluger and Rudolf Maria Huber},
  journal={Cephalalgia : an international journal of headache},
  volume={24 1},
In a randomized, double-blind cross-over study 10 subjects were exposed to a simulated altitude of 4500 m for 10 h after administration of placebo, acetozolamide (250 mg bid) or theophylline (250 mg bid). T2-weighted magnetic resonances images (MRI) and diffusion weighted MRI were obtained directly after exposure to altitude under hypoxic conditions. Although eight of 10 subjects had moderate to severe acute mountain sickness (AMS), we found no evidence of cerebral oedema, irrespective of the… CONTINUE READING
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