No evidence of brain cell degeneration after long-term sleep deprivation in rats

@article{Cirelli1999NoEO,
  title={No evidence of brain cell degeneration after long-term sleep deprivation in rats},
  author={C. Cirelli and P. Shaw and A. Rechtschaffen and G. Tononi},
  journal={Brain Research},
  year={1999},
  volume={840},
  pages={184-193}
}
Sleep deprivation leads to cognitive impairments in humans and, if sustained for 2-3 weeks in rats, it is invariably fatal. It has been suggested that neural activity associated with waking, if it is not interrupted by periods of sleep, may damage brain cells through excitotoxic or oxidative mechanisms and eventually lead to cell death. To determine whether sustained waking causes brain cell degeneration, three parallel strategies were used. The presence and extent of DNA fragmentation was… Expand
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