No evidence of a functionally significant polymorphism of the BCL2 gene in Danish, Finnish and Basque type 1 diabetes families

@article{Heding2001NoEO,
  title={No evidence of a functionally significant polymorphism of the BCL2 gene in Danish, Finnish and Basque type 1 diabetes families},
  author={PE Heding and A. E. Karlsen and Riitta K. Veijola and J\orn Nerup and Flemming Pociot},
  journal={Genes and Immunity},
  year={2001},
  volume={2},
  pages={398-400}
}
Accumulating evidence has suggested a role for the anti-apoptotic protein BCL2 in the development of autoimmune diseases, including type 1 diabetes mellitus (T1DM). Recently, the first BCL2 polymorphism (Ala43Thr) with association to T1DM in a Japanese population was reported. The polymorphism was found significantly more frequent in control individuals (14.5%) than in T1DM patients (6.8%), and was furthermore found to be functionally relevant, promoting a increased sensitivity to apoptosis… CONTINUE READING

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