No evidence of a change in HIV-1 virulence since 1996 in France.

  title={No evidence of a change in HIV-1 virulence since 1996 in France.},
  author={P{\'e}n{\'e}lope Troude and M J Chaix and Laurent Tran and Christiane Deveau and R{\'e}monie Seng and J F Delfraissy and Christine Rouzioux and C{\'e}cile Goujard and Laurence Meyer},
  volume={23 10},
OBJECTIVE We investigated temporal trends in the CD4 cell count and in plasma HIV RNA and total HIV DNA levels measured at the time of primary HIV infection, as proxies for HIV-1 virulence, taking changes in patient characteristics into account. DESIGN We studied 903 patients enrolled during primary HIV infection in the French multicenter ANRS PRIMO cohort from 1996 to 2007. METHODS Associations between the year of primary HIV infection and the values of the three markers were tested with… CONTINUE READING

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