No evidence of Peutz-Jeghers syndrome gene LKB1 involvement in left-sided colorectal carcinomas.

@article{Launonen2000NoEO,
  title={No evidence of Peutz-Jeghers syndrome gene LKB1 involvement in left-sided colorectal carcinomas.},
  author={Virpi Launonen and Egle Avizienyte and Anu Loukola and P{\"a}ivi Laiho and Reijo Salovaara and Hannu J{\"a}rvinen and Jukka-Pekka Mecklin and Asuka Oku and Miyuki Shimane and Hee Chan Kim and Jin Cheon Kim and Jun-ichi Nezu and Lauri A. Aaltonen},
  journal={Cancer research},
  year={2000},
  volume={60 3},
  pages={546-8}
}
LKB1 serine/threonine kinase is a gene for Peutz-Jeghers cancer predisposition syndrome. Most studies have detected a low frequency of LKB1 defects in sporadic cancer. A notable exception is a recent report describing frequent, mostly missense type, LKB1 mutations in Korean distal colorectal tumors. To clarify the role of LKB1 in colon cancer, we scrutinized 50 left-sided Korean and Finnish specimens. No somatic mutations were found. The seven Korean somatic missense mutations reported… CONTINUE READING
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