No evidence for viral sequences in five lepidic adenocarcinomas (former “BAC”) by a high-throughput sequencing approach

Abstract

The hypothesis of an infectious etiology of the formerly named bronchiolo-alveolar carcinoma (BAC) has raised controversy. We investigated tumor lung tissues from five patients with former BAC histology using high-throughput sequencing technologies to discover potential viruses present in this type of lung cancer. Around 180 million single reads of 100 bases were generated for each BAC sample. None of the reads showed a significant similarity for Jaagsiekte sheep retrovirus (JSRV) and no other viruses were found except for endogenous retroviruses. In conclusion, we have demonstrated the absence of JSRV and other known human viruses in five samples of well-characterized lepidic adenocarcinoma.

DOI: 10.1186/s13104-015-1669-8

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@inproceedings{Berthet2015NoEF, title={No evidence for viral sequences in five lepidic adenocarcinomas (former “BAC”) by a high-throughput sequencing approach}, author={Nicolas Berthet and L. Frangeul and Ken Andr{\'e} Olaussen and Elisabeth M Brambilla and Nicolas Dorvault and Philippe Girard and Pierre Validire and {\'E}lie Fadel and Christiane Bouchier and Antoine Gessain and Jean-Charles Soria}, booktitle={BMC Research Notes}, year={2015} }