No evidence for the H133Y mutation in SONIC HEDGEHOG in a collection of common tumour types

@article{Wicking1998NoEF,
  title={No evidence for the H133Y mutation in SONIC HEDGEHOG in a collection of common tumour types},
  author={Carol Wicking and Timothy Evans and Bettina Henk and Nicholas John Hayward and Lisa A. Simms and Georgia Chenevix-Trench and Torsten Pietsch and Brandon Wainwright},
  journal={Oncogene},
  year={1998},
  volume={16},
  pages={1091-1093}
}
The human homologue of the Drosophila segment polarity gene patched is mutated in the cancer predisposition syndrome naevoid basal cell carcinoma syndrome (NBCCS), as well as in several types of tumour associated with the disorder. It was recently reported that a single recurrent mutation in the SONIC HEDGEHOG gene, which encodes the PATCHED ligand, was found in one of 43 basal cell carcinomas (BCCs), one of 14 medulloblastomas and one of six breast carcinomas analysed (. We have searched… CONTINUE READING
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