No evidence for mouse pancreatic beta-cell epithelial-mesenchymal transition in vitro.

@article{Atouf2007NoEF,
  title={No evidence for mouse pancreatic beta-cell epithelial-mesenchymal transition in vitro.},
  author={Fouad Atouf and Cheol Hong Park and Klaus Pechhold and Malancha Ta and Yong Choi and Nadya L Lumelsky},
  journal={Diabetes},
  year={2007},
  volume={56 3},
  pages={699-702}
}
We used cre/loxP-based genetic lineage tracing analysis to test a previously proposed hypothesis that in vitro cultured adult pancreatic beta-cells undergo epithelial-mesenchymal transition (EMT) to generate a highly proliferative, differentiation-competent population of mesenchymal islet "progenitor" cells. Our results in the mouse that are likely to be directly relevant to the human system show that adult mouse beta-cells do not undergo EMT in vitro and that the mesenchymal cells that arise… CONTINUE READING

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