No evidence for feedback inhibition of hepatic apolipoprotein B (apo B) production after extracorporeal low density lipoprotein precipitation as determined by [1-13C]leucine infusion in normal volunteers.

@article{Arends1993NoEF,
  title={No evidence for feedback inhibition of hepatic apolipoprotein B (apo B) production after extracorporeal low density lipoprotein precipitation as determined by [1-13C]leucine infusion in normal volunteers.},
  author={Joop J A Arends and Dennis M. Bier and G{\"u}nter Sch{\"a}fer and Victor William Armstrong and Joachim Thiery and Dietrich Seidel and Peter Schauder},
  journal={European journal of clinical investigation},
  year={1993},
  volume={23 10},
  pages={602-14}
}
To determine the impact of an acute reduction of the circulating mass of apolipoprotein B (apo B) on apo B metabolism we studied six healthy male volunteers before (day 0), 1 day after (day 2), and 7 days after (day 8) an LDL apheresis treatment which reduced apo B mass by 59%. Appearance of newly synthesized apo B in plasma VLDL and LDL was studied using a primed-constant infusion of [1-13C]-leucine. VLDL apo B pool size and fractional VLDL apo B production rate calculated using a one… CONTINUE READING

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