No evidence for dualism in function and receptors: PD-L2/B7-DC is an inhibitory regulator of human T cell activation.

@article{Pfistershammer2006NoEF,
  title={No evidence for dualism in function and receptors: PD-L2/B7-DC is an inhibitory regulator of human T cell activation.},
  author={Katharina Pfistershammer and Christoph Klauser and Winfried F. Pickl and Johannes St{\"o}ckl and Judith Leitner and Gerhard J. Zlabinger and Otto Majdic and Peter Steinberger},
  journal={European journal of immunology},
  year={2006},
  volume={36 5},
  pages={
          1104-13
        }
}
The B7 family member programmed-death-1-ligand 2 (PD-L2/B7-DC) is a ligand for programmed-death-receptor 1 (PD-1), a receptor involved in negative regulation of T cell activation. Several independent studies have reported that PD-L2, however, can also potently costimulate murine T cells via an additional yet unidentified receptor. In this study, we evaluated the contribution of PD-L2 to the activation of human T cells using a novel system of engineered T cell stimulators that expresses membrane… CONTINUE READING
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