No evidence for an association of polymorphisms of the tryptophan hydroxylase gene with affective disorders or attempted suicide among Japanese patients.

@article{Kunugi1999NoEF,
  title={No evidence for an association of polymorphisms of the tryptophan hydroxylase gene with affective disorders or attempted suicide among Japanese patients.},
  author={Hiroshi Kunugi and Satoru Ishida and Tadafumi Kato and Toshiaki Sakai and Masahiko Tatsumi and Tetsuya Hirose and Shinichiro Nanko},
  journal={The American journal of psychiatry},
  year={1999},
  volume={156 5},
  pages={774-6}
}
OBJECTIVE Tryptophan hydroxylase is the rate-limiting enzyme in the biosynthesis of serotonin. The authors examined whether polymorphisms A218C and A779C in intron 7 of the tryptophan hydroxylase gene are associated with a risk for affective disorders or suicidal behavior. METHOD Subjects were 141 patients with bipolar disorder and 73 patients with unipolar affective disorder, 46 of whom had a history of attempted suicide, and 208 healthy volunteers. All subjects were unrelated to each other… CONTINUE READING

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