No evidence for allelic association of a human CTLA-4 promoter polymorphism with autoimmune thyroid disease in either population-based case-control or family-based studies.

@article{Heward1998NoEF,
  title={No evidence for allelic association of a human CTLA-4 promoter polymorphism with autoimmune thyroid disease in either population-based case-control or family-based studies.},
  author={Joanne M. Heward and Amit Allahabadia and Jackie D Carr-Smith and Jacqueline Daykin and Clive Stewart Cockram and Caroline Gordon and Anthony Barnett and Jayne A. Franklyn and Stephen C. L. Gough},
  journal={Clinical endocrinology},
  year={1998},
  volume={49 3},
  pages={331-4}
}
OBJECTIVE The cytotoxic T lymphocyte associated-4 (CTLA-4) gene is a candidate for T-cell mediated autoimmune disease and polymorphism has been reported to be associated with both type 1 diabetes and autoimmune thyroid disease. A previously unreported polymorphism of the promoter region of the human CTLA-4 gene has recently been described in a sample of a normal control population. We investigated the distribution of this polymorphism, situated at position -318 to the ATG start codon and… CONTINUE READING

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