No evidence for a physiological coupling between melatonin and glucocorticoids

@article{Hajak1997NoEF,
  title={No evidence for a physiological coupling between melatonin and glucocorticoids},
  author={Goeran Hajak and Andrea Rodenbeck and Hans-Dietrich Ehrenthal and Sabine Leonard and Dirk Wedekind and Georgios Sengos and Danyi Zhou and Gerald Huether},
  journal={Psychopharmacology},
  year={1997},
  volume={133},
  pages={313-322}
}
Much has been speculated about the existence of a physiological coupling between melatonin and glucocorticoid secretion and about a possible anti-stress action of melatonin. We examined the relationship between melatonin and glucocorticoid secretion under close-to-physiological conditions, when the plasma concentration of either melatonin or glucocorticoids was elevated acutely or chronically in both rats and humans. Tryptophan administration caused a massive rise of plasma melatonin, but had… CONTINUE READING

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