No end in sight for telomerase-targeted cancer drugs

  title={No end in sight for telomerase-targeted cancer drugs},
  author={Sarah C. P. Williams},
  journal={Nature Medicine},
  • Sarah C. P. Williams
  • Published 2013
  • Medicine
  • Nature Medicine
  • On paper at least, the telomerase enzyme seems like a perfect cancer target. Telomerase expression is essential for the proliferation of most cancer cells, but the enzyme is inactive in the majority of normal human tissues. That means that inhibiting the chromosomeelongating enzyme should, in theory, be a relatively safe and effective way to, if not directly kill, at least weaken cancer cells before treating with other agents. Putting that idea into practice has proven more difficult than drug… CONTINUE READING
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