No effect of folic acid supplementation on cardiovascular events, cancer or mortality after 5 years in people at increased cardiovascular risk, although homocysteine levels are reduced

@article{Bazzano2011NoEO,
  title={No effect of folic acid supplementation on cardiovascular events, cancer or mortality after 5 years in people at increased cardiovascular risk, although homocysteine levels are reduced},
  author={L. Bazzano},
  journal={Evidence Based Medicine},
  year={2011},
  volume={16},
  pages={117 - 118 - 31}
}
  • L. Bazzano
  • Published 2011
  • Medicine
  • Evidence Based Medicine
Commentary on: ClarkeRHalseyJLewingtonS.; B-Vitamin Treatment Trialists' Collaboration. Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: meta-analysis of 8 randomized trials involving 37 485 individuals. Arch Intern Med 2010;170:1622–31. 
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Meta-analysis of folic acid supplementation trials on risk of cardiovascular disease and risk interaction with baseline homocysteine levels.
TLDR
Analysis of within-trial results stratified by baseline homocysteine suggests potential harm in those with high homocy steine at baseline, and FA supplementation should not be recommended as a means to prevent or treat CVD or stroke. Expand
Efficacy of folic acid supplementation in stroke prevention: a meta-analysis
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It is indicated that folic acid supplementation can effectively reduce the risk of stroke in primary prevention and should be considered as a standalone treatment for stroke prevention. Expand
Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: Meta-analysis of 8 randomized trials involving 37 485 individuals.
TLDR
Dietary supplementation with folic acid to lower homocysteine levels had no significant effects within 5 years on cardiovascular events or on overall cancer or mortality in the populations studied. Expand
Reconciling the Evidence on Serum Homocysteine and Ischaemic Heart Disease: A Meta-Analysis
Background Results from genetic epidemiological studies suggest that raised serum homocysteine is a cause of ischaemic heart disease, but the results of randomised trials suggest otherwise. We aimedExpand