No effect of anti-oxidative therapy on cerebral amyloidosis following ischemia-reperfusion brain injury.

Abstract

The distribution patterns of amyloid precursor protein (APP) fragments were studied immunocytochemically in the rat brain before, after 10 min ischemia and following treatment by idebenone. Six months after brain ischemia intense staining for APP appeared in extra- and intracellular space. These findings indicate that APP is involved in the degeneration… (More)

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