No effect of L-arginine supplementation on pulmonary endothelial dysfunction after cardiopulmonary bypass.

@article{Angdin2001NoEO,
  title={No effect of L-arginine supplementation on pulmonary endothelial dysfunction after cardiopulmonary bypass.},
  author={Monika Angdin and G{\"o}ran Settergren and Jan Li{\vs}ka and R Astudillo},
  journal={Acta anaesthesiologica Scandinavica},
  year={2001},
  volume={45 4},
  pages={441-8}
}
BACKGROUND Acetylcholine is an endothelium-dependent vasodilator through the L-arginine-nitric oxide pathway. After ischemia-reperfusion this effect is attenuated, also demonstrated in the pulmonary circulation after cardiopulmonary bypass. Administration of L-arginine has been shown to have a protective effect on endothelial function in reperfusion injury. The aim of the current study was to test the possible effect of L-arginine on the acetylcholine reactivity in the pulmonary circulation… CONTINUE READING