No detectable increase in sister chromatid exchanges in lymphocytes from mycosis fungoides patients after topical treatment with nitrogen mustard.

We measured sister chromatid exchanges (SCEs) in lymphocytes of eight MF patients before, and 2 h, and 24 h after treatment with topical nitrogen mustard. The mean number of SCEs/cell (+/- SEM) were 8.15 (+/- 0.62), 8.34 (+0.55) and 8.26 (+/- 0.56), respectively. The 2 h and 24 h results do not differ significantly from pretreatment levels. Our results show… (More)