No correlation between the expression of FXR and genes involved in multidrug resistance phenotype of primary liver tumors.

Abstract

Farnesoid X receptor (FXR) has been recently reported to enhance chemoresistance through bile acid-independent mechanisms. Thus, FXR transfection plus activation with GW4064 resulted in reduced sensitivity to cisplatin-induced toxicity. This is interesting because primary tumors of the liver, an organ where FXR is expressed, exhibit marked refractoriness to… (More)
DOI: 10.1021/mp300028a

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Cite this paper

@article{MartinezBecerra2012NoCB, title={No correlation between the expression of FXR and genes involved in multidrug resistance phenotype of primary liver tumors.}, author={Pablo Martinez-Becerra and Javier Vaquero and Margarita Romero and Encarnaci{\'o}n Lozano and C Anad{\'o}n and Rocio I R Macias and M. A. Serrano and Nat{\`a}lia Gra{\~n}{\'e}-Boladeras and Lu{\'i}s Mu{\~n}oz-Bellv{\'i}s and L. F. Alvarez and Bruno Sangro and Marçal Pastor-Anglada and J Gonzalo Mar{\'i}n}, journal={Molecular pharmaceutics}, year={2012}, volume={9 6}, pages={1693-704} }