No correlation between body mass index and striatal dopamine transporter availability in healthy volunteers using SPECT and [123I]PE2I.

@article{Thomsen2013NoCB,
  title={No correlation between body mass index and striatal dopamine transporter availability in healthy volunteers using SPECT and [123I]PE2I.},
  author={Gerda Thomsen and Morten Ziebell and Pia S\ondergaard Jensen and S da Cuhna-Bang and Gitte Moos Knudsen and Lars H. Pinborg},
  journal={Obesity},
  year={2013},
  volume={21 9},
  pages={1803-6}
}
OBJECTIVE Dopamine plays an important role in both the rewarding and conditioning effects of food. These effects involve mesolimbic, mesocortical, and nigrostriatal pathways. In humans, the most consistent finding has been reduced striatal dopamine D2/3 receptor availability. In striatum, dopamine is inactivated by reuptake via the dopamine transporter (DAT). The aim of the study was to test the hypothesis of lower DAT availability in obese healthy subjects using a selective DAT radiotracer in… CONTINUE READING

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