No correction, no retraction, no apology, no comment: paroxetine trial reanalysis raises questions about institutional responsibility

@article{Doshi2015NoCN,
  title={No correction, no retraction, no apology, no comment: paroxetine trial reanalysis raises questions about institutional responsibility},
  author={Peter Doshi},
  journal={BMJ : British Medical Journal},
  year={2015},
  volume={351}
}
  • P. Doshi
  • Published 2015
  • Medicine
  • BMJ : British Medical Journal
As a new data analysis adds weight to calls for retraction of a paper on paroxetine in adolescents, Peter Doshi examines the resistance to action of a professional society, its journal, and an Ivy League university 

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References

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Restoring invisible and abandoned trials: a call for people to publish the findings
TLDR
Peter Doshi and colleagues call for sponsors and investigators of abandoned studies to publish (or republish) and propose a system for independent publishing if sponsors fail to respond. Expand
Restoring Study 329: efficacy and harms of paroxetine and imipramine in treatment of major depression in adolescence
TLDR
The reanalysis of Study 329 illustrates the necessity of making primary trial data and protocols available to increase the rigour of the evidence base and access to primary data from trials has important implications for both clinical practice and research. Expand
Efficacy of paroxetine in the treatment of adolescent major depression: a randomized, controlled trial.
TLDR
Paroxetine demonstrated significantly greater improvement compared with placebo in Hamilton Rating Scale for Depression total score < or = 8, HAM-D depressed mood item, K-SADS-L depressed Mood item, and CGI score of 1 or 2. Expand