No contribution of the ABCB11 p.444A polymorphism in Japanese patients with drug-induced cholestasis.

@article{Kagawa2015NoCO,
  title={No contribution of the ABCB11 p.444A polymorphism in Japanese patients with drug-induced cholestasis.},
  author={Tatehiro Kagawa and Shunji Hirose and Yoshitaka Arase and Akira Oka and Kazuya Anzai and Kota Tsuruya and Koichi Shiraishi and Reiko Orii and Satsuki Ieda and Takahide Nakazawa and Kengo Tomita and Ryota Hokari and Soichiro Miura and Hirotoshi Ebinuma and Hidetsugu Saito and Tsuneo Kitamura and Yoshinori Horie and Chiaki Okuse and Mitsuru Wasada and Hidetoshi Inoko and Masahiro Tohkin and Yoshiro Saito and Keiko Maekawa and Hajime Takikawa and Tetsuya Mine},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2015},
  volume={43 5},
  pages={
          691-7
        }
}
European studies have revealed that the ABCB11 c.1331T>C (V444A) polymorphism (rs2287622) C-allele frequency is higher among patients with drug-induced cholestasis. Given the low incidence of this disease, however, this association has not been sufficiently elucidated. We aimed to investigate the significance of this polymorphism in Japanese patients. We determined ABCB11 V444A polymorphism frequencies and HLA genotypes in two independent drug-induced cholestasis cohorts. Expression and… CONTINUE READING

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