No cerebrocervical venous congestion in patients with multiple sclerosis

  title={No cerebrocervical venous congestion in patients with multiple sclerosis},
  author={Florian Doepp and Friedemann Paul and Jos{\'e} Manuel Valdueza and Klaus Schmierer and Stephan Schreiber},
  journal={Annals of Neurology},
Multiple sclerosis (MS) is characterized by demyelination centered around cerebral veins. Recent studies suggested this topographic pattern may be caused by venous congestion, a condition termed chronic cerebrospinal venous insufficiency (CCSVI). Published sonographic criteria of CCSVI include reflux in the deep cerebral veins and/or the internal jugular and vertebral veins (IJVs and VVs), stenosis of the IJVs, missing flow in IJVs and VVs, and inverse postural response of the cerebral venous… 
Chronic cerebrospinal venous insufficiency and venous stenoses in multiple sclerosis
Assessment of the prevalence of CCSVI in Danish MS patients using sonography and comparing these findings with MRI measures of venous flow and morphology finds that the disease is more likely to be an autoimmune disease than a vascular disease.
Brain Hyperechogenicities are not Associated with Venous Insufficiency in Multiple Sclerosis: A Pilot Neurosonology Study
Transcranial sonography reveals brain parenchyma hyperechogenic alterations (BPHA) that are thought to reflect iron accumulation, and potential association of BPHA with chronic cerebrospinal venous insufficiency (CCSVI) in MS is investigated.
No Association of Chronic Cerebrospinal Venous Insufficiency with Multiple Sclerosis
  • R. FoxC. Diaconu Esther SH Kim
  • Medicine, Psychology
    Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
  • 2015
Five venous characteristics were recommended to evaluate CCSVI: criterion 1 evaluates extracranial reflux in the internal jugular or vertebral veins in sitting and supine positions, and criterion 5 assesses reverted postural control of the main cerebral venous outflow pathway.
Multiple Sclerosis and Chronic Cerebrospinal Venous Insufficiency: The Neuroimaging Perspective
In patients with multiple sclerosis (MS), Zamboni et al[1][1] described anomalies of venous outflow at color Doppler high-resolution examination and multiple severe extracranial stenosis at
Chronic cerebrospinal venous insufficiency in multiple sclerosis: diagnostic, pathogenetic, clinical and treatment perspectives
There is an urgent need to define and validate the spectrum of cranial/extracranial venous anomalies and to establish reliable, diagnostic gold-standard test(s) for CCSVI.
Endovascular Therapy for Chronic Cerebrospinal Venous Insufficiency in Multiple Sclerosis
The proposed association between CCSVI and MS is described, the current data are summarized, the role of endovascular therapy is discussed, and the need for rigorous randomized clinical trials to evaluate this association and treatment is discussed.
No evidence of chronic cerebrospinal venous insufficiency at multiple sclerosis onset
This hypothesis that chronic cerebrospinal venous drainage is the possible cause of multiple sclerosis is investigated by studying the occurrence of CCSVI in clinically isolated syndromes (CISs) suggestive of MS.
Extra-cranial venous flow in patients with multiple sclerosis
[No support for the hypothesis of chronic cerebrospinal venous insufficiency in multiple sclerosis].
Evaluating the jugular veins using duplex sonography in patients with multiple sclerosis found that vascular intervention in MS is not recommended and IJV changes that meet the CCSVI criteria have not been found.


Chronic cerebrospinal venous insufficiency and multiple sclerosis
The recent investigations that led to the description of CCSVI are discussed as well as the conceptual and technical shortcomings that challenge the potential relationship of this phenomenon to MS.
Venous and cerebrospinal fluid flow in multiple sclerosis: A case‐control study
There is no evidence confirming the suggested vascular multiple sclerosis hypothesis, and there are no differences regarding internal jugular venous outflow, aqueductal cerebrospinal fluid flow, or the presence ofinternal jugular blood reflux.
Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis
CDMS is strongly associated with CCSVI, a scenario that has not previously been described, characterised by abnormal venous haemodynamics determined by extracranial multiple venous strictures of unknown origin.
Anomalous Venous Blood Flow and Iron Deposition in Multiple Sclerosis
  • A. V. SinghP. Zamboni
  • Medicine, Psychology
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2009
The hypothesis that iron deposits in MS are a consequence of altered cerebral venous return and chronic insufficient venous drainage is supported and several recently published studies support the hypothesis that MS progresses along the venous vasculature.
The value of cerebral Doppler venous haemodynamics in the assessment of multiple sclerosis
Internal jugular vein valve incompetence in COPD and primary pulmonary hypertension
The aim of this study was to analyze the prevalence of IJVVI in patients with COPD and PPH using duplex sonography (DUS).
Blood Flow Velocities in the Vertebral Veins of Healthy Subjects: A Duplex Sonographic Study
The authors report duplex sonographic findings in 138 healthy subjects without central nervous disease that may be of relevance when discussing flow velocities in the vertebral veins in cases of cerebrovenous disorders or in patients after neck dissection.
The pathology of multiple sclerosis.