No carcinogenicity of ethyl tertiary-butyl ether by 2-year oral administration in rats.

@article{Suzuki2012NoCO,
  title={No carcinogenicity of ethyl tertiary-butyl ether by 2-year oral administration in rats.},
  author={Masaaki Suzuki and Kazunori Yamazaki and Hirokazu Kano and Shigetoshi Aiso and Kasuke Nagano and Shoji Fukushima},
  journal={The Journal of toxicological sciences},
  year={2012},
  volume={37 6},
  pages={1239-46}
}
The carcinogenicity of ethyl tertiary-butyl ether (ETBE) was examined by oral administration using F344/DuCrlCrlj rats. Groups of 50 male and 50 female rats were given drinking water containing ETBE at doses of 0, 625, 2,500 or 10,000 ppm (w/w) for 104 weeks. No significant increase in the incidence of tumors was detected in any organ of either sex. Rat-specific non-neoplastic lesions were observed in the kidney: An increase in the severity of chronic progressive nephropathy was observed in the… CONTINUE READING