No benefit of adjuvant Fluorouracil Leucovorin chemotherapy after neoadjuvant chemoradiotherapy in locally advanced cancer of the rectum (LARC): Long term results of a randomized trial (I-CNR-RT).

@article{Sainato2014NoBO,
  title={No benefit of adjuvant Fluorouracil Leucovorin chemotherapy after neoadjuvant chemoradiotherapy in locally advanced cancer of the rectum (LARC): Long term results of a randomized trial (I-CNR-RT).},
  author={A. Sainato and Valentina Cernusco Luna Nunzia and V. Valentini and A. De Paoli and Enrici Riccardo Maurizi and M. Lupattelli and C. Aristei and C. Vidali and M. Conti and A. Galardi and P. Ponticelli and M. L. Friso and T. Iannone and F. Osti and B. Manfredi and M. Coppola and C. Orlandini and L. Cionini},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  year={2014},
  volume={113 2},
  pages={
          223-9
        }
}
BACKGROUND AND PURPOSE To evaluate the effect of adjuvant chemotherapy (ACT) in locally advanced rectal cancer (LARC) after neoadjuvant chemoradiation (NACT-RT. [...] Key Method NACT-RT consisted of 45Gy/28/ff concurrent with 5FU (350mg/sqm) and Folinic Acid (20mg/sqm) on days 1-5 and 29-33; surgery was performed after 4-6weeks. Median follow up was 63·7months. Primary end point was overall survival (OS). Expand
Chemoradiation, surgery and adjuvant chemotherapy versus induction chemotherapy followed by chemoradiation and surgery: long-term results of the Spanish GCR-3 phase II randomized trial†.
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