No attenuation of ischaemic preconditioning by the calcium antagonist nisoldipine.

@article{Wallbridge1996NoAO,
  title={No attenuation of ischaemic preconditioning by the calcium antagonist nisoldipine.},
  author={D R Wallbridge and Rainer Schulz and Claude Braun and Heiner Post and Gerd Heusch},
  journal={Journal of molecular and cellular cardiology},
  year={1996},
  volume={28 8},
  pages={1801-10}
}
In anaesthetized dogs, intracoronary infusion of calcium prior to a prolonged ischaemic period reduced infarct size, thereby mimicking the protective effects of ischaemic preconditioning and suggesting that an increase in the intracellular calcium concentration might be an important mechanism underlying this phenomenon. The aim was to determine whether pretreatment with the calcium antagonist nisoldipine attenuates the reduction in infarct size achieved by ischaemic preconditioning. In 10… CONTINUE READING