No associations of human pulmonary tuberculosis with Sp110 variants.

  title={No associations of human pulmonary tuberculosis with Sp110 variants.},
  author={Thorsten Thye and Edmund N. L. Browne and Margaret Amanua Chinbuah and John Owusu Gyapong and Ivy Frances Osei and Ellis Owusu-Dabo and Stefan Niemann and Sabine Ruesch-Gerdes and R Horstmann and Christian Meyer},
  journal={Journal of medical genetics},
  volume={43 7},
BACKGROUND After a recent report on the role of the Ipr1 gene in mediating innate immunity in a mouse model of Mycobacterium tuberculosis infection, the human Ipr1 homologue, Sp110, was considered a promising candidate for an association study in human tuberculosis. METHODS In a sample of >1000 sputum positive, HIV negative West African patients with pulmonary tuberculosis and >1000 exposed, apparently healthy controls, we have genotyped 21 Sp110 gene variants that were either available from… CONTINUE READING


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