No association or linkage between an intronic polymorphism of presenilin‐1 and sporadic or late‐onset familial Alzheimer disease

@article{Scott1997NoAO,
  title={No association or linkage between an intronic polymorphism of presenilin‐1 and sporadic or late‐onset familial Alzheimer disease},
  author={William K. Scott and L. Yamaoka and P. A. Locke and B. L. Rosi and Peter C. Gaskell and Ann M Saunders and P. Michael Conneally and Gary W. Small and Lindsay A. Farrer and John Growdon and Allen D. Roses and Margaret A. Pericak-Vance and Jonathan L. Haines},
  journal={Genetic Epidemiology},
  year={1997},
  volume={14}
}
Recent reports have shown an association between an intronic polymorphism of the presenilin‐1 (PSEN1) gene and late‐onset (age at onset > 65) familial and sporadic (no family history) Alzheimer disease (AD). The reported association was independent of the effect of the only previously identified gene associated with late‐onset AD, APOE. Blood samples were obtained from members of 122 multiplex AD families, 42 unrelated cases of AD with positive family histories of dementia, 456 sporadic cases… 
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No association between a presenilin 1 polymorphism and Alzheimer disease.
TLDR
The relationship between the PS1 intron 8 polymorphism and LOAD could not be confirmed in this collection of families and traditional linkage methods were applied.
No association between presenilin 1 (PS1) intronic polymorphism and sporadic Alzheimer's disease in Koreans
TLDR
The PS1 intronic polymorphism did not modify the risk for sporadic AD, neither independently nor synergistically with the APOE ε4 allele or ACT A allele, in Koreans.
No association between an intronic polymorphism in the presenilin-1 gene and Alzheimer disease in a German population
Presenilin-1 Gene Intronic Polymorphism and Late-onset Alzheimer's Disease
TLDR
The results showed that the 1/1 genotype does not increase the risk of developing late-onset Alzheimer's disease in the Turkish population.
Variable expression of presenilin 1 is not a major determinant of risk for late-onset Alzheimer's Disease
TLDR
The results do not support a major role for variable expression of PSEN1 in LOAD and re-analysed all published literature on the PSen1 intronic polymorphism in a meta-analysis.
Association between presenilin 1 intronic polymorphism and late onset Alzheimer's disease in the North Chinese population
Association study and meta-analysis of Alzheimer's disease risk and presenilin-1 intronic polymorphism
Lack of association of presenilin-1 intron-8 polymorphism with neuropathological features of Alzheimer's disease
No association between the HLA-A2 allele and Alzheimer disease
TLDR
It is concluded that the HLA-A2 allele did not influence AD risk or onset age in this study population, and population differences, including stratification sub-structures, and other undetermined factors could contribute to discrepant findings among studies.
Genetic association of two chromosome 14 genes (presenilin 1 and α1‐Antichymotrypsin) with Alzheimer's disease
TLDR
Data indicate a possible synergistic effect of these two loci on the risk of AD, and the stratification of the ACT data by PS1 genotypes showed that the risk associated with the ACT*A allele was confined to PS1*1 carriers only.
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References

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Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer's disease
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TLDR
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TLDR
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TLDR
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TLDR
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