No association of tumor necrosis factor alpha gene polymorphisms with schizophrenia or response to clozapine.

@article{Tsai2003NoAO,
  title={No association of tumor necrosis factor alpha gene polymorphisms with schizophrenia or response to clozapine.},
  author={Shih-Jen Tsai and C N Hong and Younger W-Y Yu and Chieh-Hsin Lin and L Liu},
  journal={Schizophrenia research},
  year={2003},
  volume={65 1},
  pages={27-32}
}
Tumor necrosis factor alpha (TNF-alpha), a potent immunomodulator and proinflammatory cytokine, has been implicated in schizophrenia pathogenesis and clozapine response. Two studies have established an association between schizophrenia and the TNF-alpha gene -308G/A polymorphism; however, both increased and decreased -308A allele frequency have been reported in two analogous investigations. The present study examined the hypothesis that the TNF-alpha gene -308G/A polymorphism confers… CONTINUE READING