No association of the CARD8 (TUCAN) c.30T>A (p.C10X) variant with Crohn's disease: a study in 3 independent European cohorts.

@article{Buening2008NoAO,
  title={No association of the CARD8 (TUCAN) c.30T>A (p.C10X) variant with Crohn's disease: a study in 3 independent European cohorts.},
  author={Carsten Buening and Hartmut H-J Schmidt and Tam{\'a}s Moln{\'a}r and Joost P. H. Drenth and Thomas Fiedler and Enno Gentz and Theodor Todorov and Daniel C Baumgart and Andreas Sturm and Ferenc Nagy and J{\'a}nos Lonovics and Dirk J de Jong and Olfert Landt and Andreas Kage and Renate G. Nickel and Janine Buettner and Herbert Lochs and Heiko Witt},
  journal={Inflammatory bowel diseases},
  year={2008},
  volume={14 3},
  pages={332-7}
}
BACKGROUND A recent study reported that the c.30T>A (p.Cys10Ter; rs2043211) variant, in the CARD8 (TUCAN) gene, is associated with Crohn's disease (CD). The aim of this study was to analyze the frequency of p.C10X in 3 independent European (IBD) cohorts from Germany, Hungary, and the Netherlands. METHODS We included a European IBD cohort of 921 patients and compared the p.C10X genotype frequency to 832 healthy controls. The 3 study populations analyzed were: (1) Germany [CD, n = 317… CONTINUE READING