No association of presenilin-1 intronic polymorphism and Alzheimer's disease in Australia.

@article{Taddei1998NoAO,
  title={No association of presenilin-1 intronic polymorphism and Alzheimer's disease in Australia.},
  author={Kevin Taddei and Deok-Hwan Yang and Christopher Fisher and Roger Clarnette and Joachim F. Hallmayer and Rebecca A. Barnetson and Rolf Maller and William S. Brooks and Stephanie Whyte and Garth A. Nicholson and Colin L. Masters and G. Anthony Broe and Sam Gandy and Ralph N. Martins},
  journal={Neuroscience letters},
  year={1998},
  volume={246 3},
  pages={178-80}
}
We screened 703 Australian subjects for an intronic polymorphism in the presenilin-1 (PS-1) gene. PS-1 intronic allele 1 homozygosity was not associated with individuals with early- or late-onset sporadic Alzheimer's disease (EOAD or LOAD). Carriers for the PS-1 intronic allele 1 were also not associated with significantly increased risk for AD regardless of gender. Our results for the Australian population are consistent with those of recent reports for other populations and do not support the… CONTINUE READING