No association of TGFB1 L10P genotypes and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a multi-center cohort study

Abstract

Background The transforming growth factor β-1 gene (TGFB1) is a plausible candidate for breast cancer susceptibility. The L10P variant of TGFB1 is associated with higher circulating levels and secretion of TGF-β, and recent large-scale studies suggest strongly that this variant is associated with breast cancer risk in the general population. Methods To evaluate whether TGFB1 L10P also modifies the risk of breast cancer in BRCA1 or BRCA2 mutation carriers, we undertook a multi-center study of 3,442 BRCA1 and 2,095 BRCA2 mutation carriers. Results We found no evidence of association between TGFB1 L10P and breast cancer risk in either BRCA1 or BRCA2 mutation carriers. The per-allele HR for the L10P variant was 1.01 (95%CI: 0.92–1.11) in BRCA1 carriers and 0.92 (95%CI: 0.81–1.04) in BRCA2 mutation carriers. Conclusions These results do not support the hypothesis that TGFB1 L10P genotypes modify the risk of breast cancer in BRCA1 or BRCA2 mutation carriers.

DOI: 10.1007/s10549-008-0064-8

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@article{Rebbeck2008NoAO, title={No association of TGFB1 L10P genotypes and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a multi-center cohort study}, author={Timothy R. Rebbeck and Antonis C. Antoniou and Trinidad Caldes Llopis and Heli Nevanlinna and Kristiina Aittom{\"a}ki and Jacques Simard and Amanda B. Spurdle and Fergus J. Couch and Lutecia H. Mateus Pereira and Mark H. Greene and Irene L. Andrulis and Boris Pasche and Virginia Kaklamani and Ute Hamann and Csilla Szabo and Susan Peock and Margaret Cook and Patricia A. Harrington and Alan Donaldson and Allison M. Male and Carol Anne Gardiner and Helen Gregory and Lucy E. Side and Anne C. Robinson and Louise Emmerson and Ian Ellis and Jean-Philippe Peyrat and Jo{\"{e}lle Fournier and Philippe Vennin and Claude Adenis and Dani{\`e}le Muller and Jean-Pierre Fricker and Michel Longy and Olga M. Sinilnikova and Dominique Stoppa-Lyonnet and Rita K. Schmutzler and Beatrix Versmold and Christoph Engel and Alfons Meindl and Karin Kast and Dieter Schaefer and Ursula G. Froster and Georgia Chenevix-Trench and Douglas F. Easton}, journal={Breast Cancer Research and Treatment}, year={2008}, volume={115}, pages={185-192} }