No association of EGF 5'UTR variant A61G and hepatocellular carcinoma in Chinese patients with chronic hepatitis B virus infection.

@article{Qi2009NoAO,
  title={No association of EGF 5'UTR variant A61G and hepatocellular carcinoma in Chinese patients with chronic hepatitis B virus infection.},
  author={Peng Qi and Hao Wang and Yue-ming Chen and Xiao-juan Sun and Yan Liu and Chunfang Gao},
  journal={Pathology},
  year={2009},
  volume={41 6},
  pages={555-60}
}
OBJECTIVE Epidermal growth factor (EGF) has many biological functions, including mitogenesis, tumorigenesis, and proliferation of epidermal tissues. Previous studies have reported that the EGF +61 (A/G) single nucleotide polymorphism in the 5'-untranslated region of the EGF gene is functional, and is associated with development of hepatocellular carcinoma (HCC) in liver cirrhosis and various malignancy. Our aim was to investigate whether EGF gene A61G polymorphism could be implicated in… CONTINUE READING

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